The Fermvyne Platform
Four integrated capabilities that take you from bench batch data to a validated fed-batch protocol — across every vessel size in your scale-up program.
Four pillars of scale-up intelligence.
Each capability is independently useful. Together they form a complete scale-up modeling workflow that covers metabolic flux, oxygen transfer, feeding strategy, and multi-scale simulation.
Metabolic Flux Modeling
Fermvyne constructs a constraint-based model of your strain's central carbon metabolism from observed batch phenotype data. The model identifies which metabolic pathways are operating near saturation — the bottlenecks that cause titer to stall at higher cell density.
Supported organisms: E. coli, P. pastoris, T. reesei, Fusarium venenatum, and custom chassis (import SBML model).
DO Profile Prediction
Dissolved oxygen is the most common failure point at scale. Fermvyne estimates kLa (the volumetric oxygen transfer coefficient) for your target vessel geometry using correlations from impeller type, agitation rate, and sparger design.
Outputs a DO% vs time curve for the entire fed-batch, flagging the depletion risk window and the agitation cascade needed to maintain DO above your setpoint.
Feed Rate Optimization
Substrate overflow — the main cause of acetate accumulation in aerobic E. coli processes — is a direct consequence of feeding faster than your cells can consume glucose oxidatively. Fermvyne optimizes the feed rate profile to stay below the critical dilution threshold while maximizing volumetric productivity.
Supports exponential feeding, linear ramp, DO-stat, and pH-stat control strategies.
Scale-Point Simulation
Run one simulation job that covers multiple vessel sizes simultaneously: 2L bench, 50L pilot, 500L pilot, 2,000L intermediate, and 10,000L+ commercial. Fermvyne adjusts kLa, mixing time, and substrate gradient assumptions at each scale automatically.
Output: a protocol card per vessel size with feed schedule, DO setpoint cascade, and agitation ramp — ready for your process binder.
Works with your existing data infrastructure.
Fermvyne connects to where your process data already lives. No reformatting, no custom ETL — import from your SCADA historian or paste a CSV.
Your strain data stays yours.
We understand that fermentation process data represents years of R&D investment. Fermvyne is designed with data isolation and confidentiality as core requirements.
TLS 1.3 in transit. AES-256 at rest. Your batch data and simulation parameters are encrypted at every layer.
Strain data never leaves your private workspace. No cross-tenant data sharing. Each organization's models and protocols are logically isolated.
We have designed the system with SOC 2 Type II controls in mind. Formal audit and certification is on our roadmap as we scale the customer base.
Role-based access control within your team workspace. Scientists can submit simulations; only administrators can manage integrations and export settings.
Enterprise customers receive a mutual NDA and data processing agreement (DPA) covering your strain IP and fermentation process data.
Configure how long simulation data and batch uploads are retained. Request deletion at any time. We do not retain data beyond your retention policy.
See the platform in action.
Schedule a technical walkthrough with Catalina — we'll run a simulation on your strain data and walk through the outputs in real time.