Platform
The enzyme design engine.
From reaction specification to ranked, expression-ready sequences in one request.
Architecture
How the pipeline works
EC Classification
Your substrate/product SMILES or enzyme class description is mapped to EC hierarchy via a fine-tuned reaction classifier, providing structural context for generation.
Generative Decoder
An autoregressive transformer decodes novel sequences conditioned on reaction embeddings. Output is not retrieval — these are sequences outside any training homolog cluster.
Biophysical Scoring
Parallel prediction heads score each candidate for E. coli expression yield category, solubility probability, and thermostability Tm range before returning ranked results.
API
One endpoint. Full pipeline.
POST your reaction context and receive ranked, expression-ready sequences in one call. The Python SDK wraps the REST API with async support and result polling built in.
Full API reference →import fermvyne
client = fermvyne.Client(api_key="fvyn_...")
result = client.design(
substrate="CC(=O)Nc1ccc(O)cc1",
product="CC(O)Nc1ccc(O)cc1",
targets={
"tm_min": 60,
"host": "ecoli",
"n_candidates": 12
}
)
for seq in result.candidates:
print(seq.fasta, seq.tm_estimate, seq.expression_score){
"job_id": "j_8xkp42",
"candidates": [
{
"rank": 1,
"fasta": "MKVLSGEDK...",
"tm_estimate": 67.4,
"expression_score": "high",
"solubility_prob": 0.91
}
]
}Integrations
Connects to your existing lab stack
Benchling ELN
Push enzyme design results directly into your Benchling notebook. FASTA sequences and prediction scores appear as structured data entries.
Python SDK
Install with pip. Full async support, automatic result polling, and pandas-compatible DataFrames for downstream analysis in your existing notebooks.
REST API
Language-agnostic JSON endpoints. Design requests, result retrieval, and pathway co-design all accessible with a single API key from your dashboard.
FASTA Export
Direct FASTA downloads formatted for Twist Bioscience and IDT gene synthesis ordering. One click from ranked candidates to synthesis order.
Run your first design request.
No wet lab required. Results in under 10 minutes.